Atalanta Flatten Parma To Return Second In Serie A
Gian Piero Gasperini's side are closing in on a third consecutive season of Champions League football as they sit two points ahead of third-placed Napoli with three games to play.
Muriel and Matteo Pessina came on after the break and the Colombian set up the Italian for the second six minutes later.
Muriel then struck twice within 10 minutes in the final quarter of an hour to bring his tally to 21 goals this campaign.
Aleksei Miranchuk grabbed a fifth in injury time after Juan Brunetta and Simon Sohm had pulled two goals back late for Parma.
Roberto De Zerbi's side are eighth, two points behind Roma, who crushed relegated Crotone 5-0 to end the capital side's four-match winless league run, days after their Europa League exit to Manchester United.
Borja Mayoral and Lorenzo Pellegrini both scored twice each with Henrikh Mkhitaryan getting his first goal in over three months.
Benevento were awarded a late penalty which could have snatched a 2-2 draw, but it was overruled after a VAR review.
Joao Pedro sealed the win for the Sardinians deep into injury time.