Multiple Mosquito Blood Meals Can Expedite Risk Of Malaria, Study


Multiple mosquito blood meals can expedite risk of malaria, study

ISLAMABAD, (UrduPoint / Pakistan Point News - 4th Jan, 2021 ) :A study lead by a team of researchers from Virginia Tech and Harvard T.H. Chan school of Public Health US claimed that multiple bouts of blood-feeding by mosquitoes shorten the incubation period for malaria parasites and increase malaria transmission potential.

Published in the open-access journal PLOS Pathogens by Lauren Childs of Virginia Tech, Flaminia Catteruccia of the Harvard T.H. Chan School of Public Health, and colleagues, shows that mosquitoes feed on blood multiple times in natural settings, the results suggest that malaria elimination may be substantially more challenging than suggested by previous experiments, which typically involve a single blood meal, Medical daily reported.

In natural settings, the female Anopheles gambiae mosquito, the major malaria vector, feeds on blood multiple times in her lifespan. Such complex behaviour is regularly overlooked when mosquitoes are experimentally infected with malaria parasites, limiting our ability to accurately describe potential effects on transmission.

In the new study, the researchers examine how additional blood-feeding affects the development and transmission potential of Plasmodium falciparum malaria parasites in 'An Gambiae' females.

"We wanted to capture the fact that, in endemic regions, malaria-transmitting mosquitoes are feeding on blood roughly every 2-3 days," says W.

Robert Shaw, a lead author of this study.

The results show that an additional blood feed three days after infection with P. falciparum accelerates the growth of the malaria parasite, thereby shortening the incubation period required before transmission to humans can occur.

Incorporating these data into a mathematical model across sub-Saharan Africa reveals that malaria transmission potential is likely higher than previously thought, making disease elimination more difficult. In addition, parasite growth is accelerated in genetically modified mosquitoes with reduced reproductive capacity, suggesting that control strategies using this approach, with the aim of suppressing Anopheles populations, may inadvertently favour malaria transmission.

The data also suggest that parasites can be transmitted by younger mosquitoes, which are less susceptible to insecticide killing, with negative implications for the success of insecticide-based strategies. Taken together, the results suggest that younger mosquitoes and those with reduced reproductive ability may provide a larger contribution to infection than previously thought.

According to the authors, the findings have important implications for accurately understanding malaria transmission potential and estimating the true impact of current and future mosquito control measures.

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