Protein Linked To Reduced Severity Of Covid
Faizan Hashmi 2 months ago Fri 30th July 2021 | 12:00 AM
ISLAMABAD, (UrduPoint / Pakistan Point News - 29th Jul, 2021 ) :Researchers have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with Covid-19.
"This is a very exciting development in the race to identify potential therapies to treat patients because there are already therapies in pre-clinical development that boost OAS1 and could be explored for their effect against SARS-CoV-2 infection," Richards added.
For the study, the team explored proteins detectable in peripheral blood as a potential target. The challenge lay in determining which proteins play a causal role in disease progression, since their levels may also be influenced by Covid-19 itself or other confounding factors, the Medical Xpress reported.
Recent advances in proteomic technology -- that is, the capacity to isolate and measure hundreds of circulating proteins at once -- combined with genetic analyses through Mendelian randomization (MR) makes possible the delicate work of untangling which proteins affected Covid-19 adverse outcomes, rather than vice versa, they added.
From genetic determinants of 931 circulating proteins, the team found that increase in OAS1 levels was associated with reduced Covid-19 death or ventilation, hospitalisation, and susceptibility in up to 14,134 Covid-19 cases and 1.2 million controls.
The results were consistent in multiple sensitivity analyses. They proceeded to measure OAS1 levels in 504 patients with different Covid-19 outcomes and found that increased OAS1 levels in post-infection patients were associated with protection against very severe Covid-19, hospitalisation and susceptibility.