Phase 2 Trial Results Of India's 1st COVID Vaccine COVAXIN Show Better Reactogenicity
Fahad Shabbir (@FahadShabbir) Published March 09, 2021 | 01:48 PM
India's first vaccine against the coronavirus, COVAXIN, has shown better reactogenicity and safety in phase 2 clinical trials compared to phase 1, according to trial results published by The Lancet Infectious Diseases medical journal
MOSCOW (UrduPoint News / Sputnik - 09th March, 2021) India's first vaccine against the coronavirus, COVAXIN, has shown better reactogenicity and safety in phase 2 clinical trials compared to phase 1, according to trial results published by The Lancet Infectious Diseases medical journal.
During phase 2 trials launched last fall, a total of 380 participants were given two doses of the Indian coronavirus vaccine four weeks apart.
"In the phase 2 trial, BBV152 [COVAXIN] showed better reactogenicity and safety outcomes, and enhanced humoral and cell-mediated immune responses compared with the phase 1 trial," the report published on Monday said.
According to the trial results, the participants developed higher neutralizing antibody titres in phase 2 compared to the previous phase, while antibody and T-cell responses induced in phase 1 remained elevated in all vaccinees 3 months after the second vaccination.
"Additionally, the proportion of participants reporting adverse events in the phase 2 trial were lower than in the phase 1 trial," the report read.
No serious side effects were reported in the study. Local adverse effects included pain and swelling at the injection site, while systemic adverse effects include fever, fatigue or malaise, myalgia, body aches, headache, nausea or vomiting, anorexia, chills, generalized rash, and diarrhea, the report added.
Last week, the vaccine's developer Bharat Biotech announced that COVAXIN demonstrated interim clinical efficacy of 81 percent in phase 3 trials. The vaccine also demonstrated "significant immunogenicity against the rapidly emerging variants." The phase 3 trials enrolled participants aged between 18 and 98, including 2,433 over the age of 60 and 4,500 with comorbidities.
Related Topics
Recent Stories
Housing Ministry prioritizes transparency in providing accommodation to federal ..
NGO donates wheelchairs to enhance accessibility & mobility for patients
Punjab Chief Minister Maryam Nawaz Sharif launches expanded health service progr ..
Minister highlights major health projects launched by CM Maryam
Mongolian envoy for boosting bilateral economic ties
GKMC achieves hundred percent results in MBBS examination
Secretary Human Rights Dept calls for setting up district level offices
Vaccination play effective role to prevent the spread of typhoid: Rashid Khan
Drive lunched to educate on proper household waste disposal
PFA destroys 300kg of dead chicken
Sindh Govt committed to clean the environment of Karachi: Mayor Karachi
Langov annoyed over law and order in Balochsitan
More Stories From World
-
Panama president-elect pledges to deport migrants who cross Darien Gap
2 hours ago -
Top opponent of India PM Modi leaves prison on bail
3 hours ago -
ICUBE-Q's initial images from space a historic day: Ambassador Hashmi
3 hours ago -
Third week of evidence wraps at Trump's criminal trial
4 hours ago -
Madinah : 3,485 Pakistani Hujjaj arrive in seamless flight operation
4 hours ago -
UN, EU officials condemn 'escalation' of violence against UNRWA
4 hours ago
-
Russia attacks Ukraine's northeast in new ground offensive
4 hours ago -
Reasons to experience magic of Sharjah Children’s Reading Festival this weekend
5 hours ago -
Paris officer 'between life and death' after police station shooting
5 hours ago -
Rafah offensive would lead to 'humanitarian disaster': UN chief
5 hours ago -
Taylor Swift fever grips Paris at start of Europe tour
5 hours ago -
S.Africa's top court hears critical Zuma election case
5 hours ago